Hemolytic Anemia Associated with Impaired Erythrocyte Shape Control

Hemolytic anemia associated with low erythrocyte ATP.

Two Cases of Chronic Hemolytic Anemia Associated with Spherocytosis

Two cases of hemolytic anemia with spherocy­tosis were investigated. lnspite of chronic hemolysis tl::crc was no radiological changes in flat bones. Ma­nagement and entity of spherocytosis is discussed m detail in this paper. 

Acquired immune hemolytic anemia associated with IgA erythrocyte coating: investigation of hemolytic mechanisms.

We have investigated the hemolytic mechanisms in a patient with acquired immune hemolytic anemia whose red cells appeared to be coated with IgA alone. The clinical course was similar to that of patients with hemolytic anemia mediated by warm-reacting IgG antibody. Splenic sequestration of red cells was demonstrated, and marked reduction of hemolysis occurred after corticosteroid therapy. Antibo...

Impaired erythrocyte phosphoribosylpyrophosphate formation in hemolytic anemia due to pyruvate kinase deficiency.

RBCs from patients with hemolytic anemia due to pyruvate kinase (PK) deficiency are characterized by a decreased total adenine and pyridine nucleotide content. Because phosphoribosylpyrophosphate (PRPP) is a precursor of both adenine and pyridine nucleotides, we investigated the ability of intact PK-deficient RBCs to accumulate PRPP. The rate of PRPP formation in normal RBCs (n = 11) was 2.89 +...

Immune hemolytic anemia associated with drug therapy.

Drug-induced immune hemolytic anemia (DIIHA) is rare; it can be mild or associated with acute severe hemolytic anemia (HA) and death. About 125 drugs have been implicated as the cause. The HA can be caused by drug-independent antibodies that are indistinguishable, in vitro and in vivo, from autoantibodies causing idiopathic warm type autoimmune hemolytic anemia (AIHA). More commonly, the antibo...